Hydrochlorothiazide: The most typical indicators and signs and symptoms of overdose noticed in individuals are Individuals brought on by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration ensuing from abnormal diuresis.

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Hydrochlorothiazide: Hydrochlorothiazide is a thiazide diuretic. Thiazides have an effect on the renal tubular mechanisms of electrolyte reabsorption, immediately expanding excretion of sodium and chloride in about equal amounts. Indirectly, the diuretic motion of hydrochlorothiazide lowers plasma quantity, with consequent will increase in plasma renin action, raises in aldosterone secretion, improves in urinary potassium loss, and decreases in serum potassium.

Angiotensin II would usually bind towards the AT1 receptor, inducing vasoconstriction and aldosterone secretion, increasing hypertension.

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